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NFL Picks: Week 7 Predictions from Odds Shark Super Computer | News, Scores, Highlights, Stats, and Rumors

Author

Andrew Mccoy

Published Mar 23, 2026

Denver Broncos quarterback Peyton Manning (18) signals at the line of scrimmage during an NFL preseason football game against the San Francisco 49ers in Santa Clara, Calif., Sunday, Aug. 17, 2014. (AP Photo/Marcio Jose Sanchez)Marcio Jose Sanchez/Associated Press

The Cleveland Browns will try to do something in Week 7 they have never done before, while Peyton Manning will attempt to make history against a team that has been historically very tough on him.

If the Odds Shark NFL prediction computer is accurate, the Browns will cover the biggest road spread in franchise history, and the San Francisco 49ers will thwart Manning’s attempt at breaking the all-time passing touchdown mark.

The computer boasts a winning record against the spread (ATS) in all six weeks so far, although it has been subpar in its Westgate SuperContest selections (where handicappers choose five games each week in a $2 million prize pool).

Week 7 started with a thud as the computer picked the New England Patriots to cover a double-digit spread against the New York Jets. They were lucky to escape with a 27-25 win, dropping the Pats to 4-13 ATS in 17 recent games when laying 10 points or more.

Cleveland is favored by 5.5 points, according to most sportsbooks monitored by Bleacher Report lines partner Odds Shark. The computer has the Browns winning, 22-11. This is just the 10th time in Browns history (current franchise) that they have been a road favorite, and they never closed higher than 3.5 points, per the Odds Shark NFL database.

The Broncos will eke out a 30-26 win over the 49ers, if the computer is correct, which would be a San Francisco cover and would probably mean that Manning would not have thrown for three touchdowns to break Brett Favre’s record of 508.

Manning has thrown just five TDs in four career games against the Niners, and his quarterback rating against them is less than 90, so history suggests he will have a tough time in Week 7.

At least one sportsbook, however, believes Manning will throw for at least three, adding a Week 7 prop at a minus-180 payout.

Week 7 Computer Predictions (Odds Shark SuperContest choices are in bold; all times ET)

NY Jets at New England Oct. 16 at 8:25 p.m.
Predicted Score: NYJ 19.5 - NE 32.3

Seattle at St. Louis Oct. 19 at 1:00 p.m. (Seattle -6.5 is a Westgate contest pick)
Predicted Score: SEA 30 - STL 14.4

Minnesota at Buffalo Oct. 19 at 1:00 p.m. (Minnesota +5.5 is a Westgate contest pick)
Predicted Score: MIN 16.4 - BUF 19.8

Tennessee at Washington Oct. 19 at 1:00 p.m. (Titans +5.5 is a Westgate contest pick)
Predicted Score: TEN 17.2 - WAS 15.2

Cleveland at Jacksonville Oct. 19 at 1:00 p.m. (Browns -5.5 is a Westgate contest pick)
Predicted Score: CLE 21.6 - JAC 10.5

Miami at Chicago Oct. 19 at 1:00 p.m.
Predicted Score: MIA 23.8 - CHI 21.9

Arizona at Oakland Oct. 19 at 4:25 p.m.
Predicted Score: ARI 27.3 - OAK 10.9

NY Giants at Dallas Oct. 19 at 4:25 p.m.
Predicted Score: NYG 20.2 - DAL 25.6

San Francisco at Denver Oct. 19 at 8:30 p.m. (Niners +6.5 is a Westgate contest pick)
Predicted Score: SF 25.8 - DEN 29.6

Houston at Pittsburgh Oct. 20 at 8:30 p.m.
Predicted Score: HOU 17.2 - PIT 22.8

Stats and odds courtesy of Odds Shark.